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CYP3A4 inducers may boost the formation on the neurotoxic/nephrotoxic ifosfamide metabolite, chloroacetaldehyde. Carefully watch people having ifosfamide with CYP3A4 inducers for toxicities and consider dose adjustment.pentobarbital will decrease the extent or impact of verapamil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Cauti